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onethreezerotwo

Member Since 20 Sep 2011
Offline May 03 2016 05:05 PM

Topics I've Started

Marijuana Usage During Pregnancy

30 October 2011 - 11:07 PM

I read through the last topic about the use of marijuana during pregnancy. It interested me, and I have access to a medical articles/papers/theses so I thought I'd do a little digging. In case you were interested, here is what I've found:

Discrete opioid gene expression impairment in the human fetal brain associated with maternal marijuana use. By: Wang, X.; Dow-Edwards, D.; Anderson, V.; Minkoff, H.; Hurd, Y. L.. Pharmacogenomics Journal, 2006, Vol. 6 Issue 4, p255-264, 10p, 3 Charts, 3 Graphs; Abstract Fetal development is a period sensitive to environmental influences such as maternal drug use. The most commonly used illicit drug by pregnant women is marijuana. The present study investigated the effects of in utero marijuana exposure on expression levels of opioid-related genes in the human fetal forebrain in light of the strong interaction between the cannabinoid and opioid systems. The study group consisted of 42 midgestation fetuses from saline-induced voluntary abortions. The opioid peptide precursors (preprodynorphin and preproenkephalin (PENK)) and receptor (mu, kappa and delta) mRNA expression were assessed in distinct brain regions. The effect of prenatal cannabis exposure was analyzed by multiple regression controlling for confounding variables (maternal alcohol and cigarette use, fetal age, sex, growth measure and post-mortem interval). Prenatal cannabis exposure was significantly associated with increased mu receptor expression in the amygdala, reduced kappa receptor mRNA in mediodorsal thalamic nucleus and reduced preproenkephalin expression in the caudal putamen. Prenatal alcohol exposure primarily influenced the kappa receptor mRNA with reduced levels in the amygdala, claustrum, putamen and insula cortex. No significant effect of prenatal nicotine exposure could be discerned in the present study group. These results indicate that maternal cannabis and alcohol exposure during pregnancy differentially impair opioid-related genes in distinct brain circuits that may have long-term effects on cognitive and emotional behaviors.The Pharmacogenomics Journal (2006) 6, 255–264. doi:10.1038/sj.tpj.6500375; published online 14 February 2006 [ABSTRACT FROM AUTHOR]; DOI: 10.1038/sj.tpj.6500375; (AN 21678577)

Effects of Marijuana Use druring Pregnancy on Newborn Cry. By: Lester, Barry M.; Dreher, Melanie. Child Development, Aug89, Vol. 60 Issue 4, p765, 7p; Abstract The effects of maternal marijuana use on the newborn cry were studied in Jamaica, where it was possible to rule out confounding factors such as the use of other substances and demographic variables that have clouded previous studies and where higher dosages may make the effects more visible. The acoustic characteristics of the cries of 20 infants of marijuana users and 20 controls were analyzed. The cries of the infants of marijuana users were shorter, has a higher percentage of dysphonation, a higher and more variable fundaments frequency, and a lower first formant than controls. There was also a dose response relation between the first formant and marijuana use. We suggest that heavy marijuana use affects the neurophysiological integrity of the infant. [ABSTRACT FROM AUTHOR]; DOI: 10.1111/1467-8624.ep9676029; (AN 9676029)

Prenatal marijuana exposure contributes to the prediction of marijuana use at age 14. By: Day, Nancy L.; Goldschmidt, Lidush; Thomas, Carrie A.. Addiction, Sep2006, Vol. 101 Issue 9, p1313-1322, 10p, 5 Charts; Abstract Aim To evaluate the effects of prenatal marijuana exposure (PME) on the age of onset and frequency of marijuana use while controlling for identified confounds of early marijuana use among 14-year-olds. Design In this longitudinal cohort study, women were recruited in their fourth prenatal month. Women and children were followed throughout pregnancy and at multiple time-points into adolescence. Setting and participants Recruitment was from a hospital-based prenatal clinic. The women ranged in age from 18 to 42, half were African American and half Caucasian, and most were of lower socio-economic status. The women were generally light to moderate substance users during pregnancy and subsequently. At 14 years, 580 of the 763 offspring–mother pairs (76%) were assessed. A total of 563 pairs (74%) was included in this analysis. Measurements Socio-demographic, environmental, psychological, behavioral, biological and developmental factors were assessed. Outcomes were age of onset and frequency of marijuana use at age 14. Findings PME predicted age of onset and frequency of marijuana use among the 14-year-old offspring. This finding was significant after controlling for other variables including the child’s current alcohol and tobacco use, pubertal stage, sexual activity, delinquency, peer drug use, family history of drug abuse and characteristics of the home environment including parental depression, current drug use and strictness/supervision. Conclusions Prenatal exposure to marijuana, in addition to other factors, is a significant predictor of marijuana use at age 14. [ABSTRACT FROM AUTHOR]; DOI: 10.1111/j.1360-0443.2006.01523.x; (AN 21857362)

The Association of Marijuana Use with Outcome of Pregnancy. By: Linn, Shai; Schoenraum, Stephen C.; Monson, Richard R.; Rosner, Richard; Stubblefield, Phillip C.; Ryan, Kenneth J.. American Journal of Public Health, Oct83, Vol. 73 Issue 10, p1161, 4p; Abstract We analyzed interview and medical record data of 12,424 women to evaluate the relationship between marijuana usage and adverse outcomes of pregnancy. Low birthweight, short gestation, and major malformations occurred more often among offspring of marijuana users. When we used logistic regression to control for demographic characteristics, habits, and medical history data, these relationships were not statistically significant. The odds ratio for the occurrence of major malformations among marijuana users was 1.36, higher than odds ratios for other exogenous variables, and the 95 per cent confidence interval was 0.97-1.91. More data are needed to establish firmly or rule out an association between marijuana usage and major malformations. Until more information is available, women should be advised not to use marijuana during pregnancy. (Am J Public Health 1983: 73;1161-1164.) [ABSTRACT FROM AUTHOR]; (AN 4947571)

Effects of prenatal tobacco, alcohol and marijuana exposure on processing speed, visual–motor coordination, and interhemispheric transfer. By: Willford, Jennifer A.; Chandler, Lynette S.; Goldschmidt, Lidush; Day, Nancy L.. Neurotoxicology & Teratology, Nov2010, Vol. 32 Issue 6, p580-588, 9p; Abstract Abstract: Deficits in motor control are often reported in children with prenatal alcohol exposure (PAE). Less is known about the effects of prenatal tobacco exposure (PTE) and prenatal marijuana exposure (PME) on motor coordination, and previous studies have not considered whether PTE, PAE, and PME interact to affect motor control. This study investigated the effects of PTE, PAE, and PME as well as current drug use on speed of processing, visual–motor coordination, and interhemispheric transfer in 16-year-old adolescents. Data were collected as part of the Maternal Health Practices and Child Development Project. Adolescents (age 16, n=320) participating in a longitudinal study of the effects of prenatal substance exposure on developmental outcomes were evaluated in this study. The computerized Bimanual Coordination Test (BCT) was used to assess each domain of function. Other important variables, such as demographics, home environment, and psychological characteristics of the mother and adolescent were also considered in the analyses. There were significant and independent effects of PTE, PAE, and PME on processing speed and interhemispheric transfer of information. PTE and PME were associated with deficits in visual–motor coordination. There were no interactions between PAE, PTE, and PME. Current tobacco use predicted deficits in speed of processing. Current alcohol and marijuana use by the offspring were not associated with any measures of performance on the BCT. [ABSTRACT FROM AUTHOR]; DOI: 10.1016/j.ntt.2010.06.004; (AN 55057659)

Parental marijuana use and risk of childhood acute myeloid leukaemia: a report from the Children's Cancer Group (United States and Canada). By: Trivers, Katrina F.; Mertens, Ann C.; Ross, Julie A.; Steinbuch, Michael; Olshan, Andrew F.; Robison, Leslie L.. Paediatric & Perinatal Epidemiology, Mar2006, Vol. 20 Issue 2, p110-118, 9p, 3 Charts; Abstract The aetiology of childhood acute myeloid leukaemia (AML) is largely unknown. Maternal marijuana use just before, or during pregnancy has been previously associated with childhood AML. This case–control investigation formally tested the hypothesis that parental marijuana use increases the risk of childhood AML in offspring. Incident cases of AML <18 years of age, diagnosed between 1989 and 1993, and registered with the Children's Cancer Group (a paediatric clinical co-operative group), were eligible for inclusion. Control children were selected via random digit dialling and individually matched 1:1 to cases on age, race and residential location, except for rare morphological subtypes that were matched 1:2. Parental telephone interviews were conducted to determine exposure and covariate information. Conditional logistic regression was used to estimate matched odds ratios (OR) and 95% confidence intervals [CI] adjusted for household income, parental education and parental age. The analysis included 517 cases and 610 matched controls. A series of sensitivity analyses examined the potential for recall bias. Ever lifetime use of marijuana by mothers was not associated with childhood AML [OR = 0.89; 95% CI = 0.66, 1.19]. Maternal marijuana use any time during the 3 months before, or during pregnancy was inversely associated with childhood AML [OR = 0.43; 95% CI = 0.23, 0.80]. Paternal use during the same time period was not associated with risk. Assuming a large degree of differential exposure misclassification was present, the corrected ORs ranged between 0.82 and 1.40. The previously reported positive association between maternal marijuana use before or during pregnancy and childhood AML was not confirmed. The decreased ORs observed in this study may be due to recall bias assuming plausibly low values of sensitivity. [ABSTRACT FROM AUTHOR]; DOI: 10.1111/j.1365-3016.2006.00700.x; (AN 19630012)



From what I've read, I've but one thing to say to mothers who refuse to stop smoking BEFORE, DURING and AFTER (at least during breastfeeding and anytime when around the child): Fuck you. Inconclusive data or not, you are potentially destroying the future of a human. And if you don't understand how something that is scientifically inconclusive still has a connotation of "Still probably a really bad idea", I'd learn fast.

What do you think about Obama sending 100 troops to Uganda?

20 October 2011 - 11:42 AM

I think it's a brilliant move for the sake of humanity. Check out this video and let me know what you think..

Is there any problems with ABing in only a single shop, longterm.

13 October 2011 - 11:54 PM

I like where I've been ABing, and I'm comfortable with it. Is it going to raise questions if I ONLY AB there, or am I in the clear?

I hate all of you.

25 September 2011 - 10:48 PM

I'm being facetious. You all make me laugh way too much, and I'm excited for some good conversation.