Well if I were to think about it, middle ear infections can be...agonizing to say the least, especially when you leave them for awhile before seeking treatment. I did that once, never ever doing that again, now when I suspect one, I deal with it right away! I was popping at least 12 Tylenol extra strength a day which is very bad. Then there is when your leg just...cramps right under the knee, moving it hurts so much, I don't even like thinking about any of this.
I guess it depends the drug... like weed I feel has more better affects than bad affects for you, I don't even view it as a drug, but the government says it is so. But when it comes to the hard stuff, I draw the line there, I guess for me it would be the way it's taken and the affects that they cause socially, physically and mentally.
I usually get 2.2 and I have never been frozen with that time and I autobuy every day. Though I still miss A LOT of items but I do get REALLY good items too. Still a good time though.